简介内容:UT-B-IN-1 (UTBINH-14) is a reversible, competitive, and selective inhibitor of the urea transporter-B (UT-B), demonstrating IC50 values of 10 nM and 25 nM for human and mouse UT-B, respectively. It exhibits low toxicity and superior selectivity against UT-B compared to UT-A isoforms. This compound enhances urine production and decreases urine concentration in mice, making UT-B-IN-1 suitable for research on diuretic mechanisms.