简介内容：AS-99 is a first-in-class, potent, and selective inhibitor of the ASH1L histone methyltransferase, exhibiting anti-leukemic activity with an IC50 value of ?M and a Kd of ?M. It inhibits cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and effectively reduces leukemia burden in vivo.
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