简介内容：EP39, a potent HIV-1 maturation inhibitor, binds to the QVT motif within the SP1 domain of Gag, reducing the dynamics at the CA-SP1 junction and disrupting the coil-helix equilibrium adjacent to the SP1 domain by stabilizing the transient alpha-helical structure. This action arrests HIV-1 maturation, effectively blocking its infectivity.
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