简介内容：SJ10542, a phenyl glutarimide (PG)-PROTAC, demonstrates potent and selective activity against JAK2/3 by exhibiting DC50 values of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. It employs a PG ligand for cereblon (CRBN) recruitment [1].
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