简介内容:ALK-IN-21 (Compound B10), a proficient ALK inhibitor targeting the ALKG1202R mutation, demonstrates significant inhibitory activity, with IC50 values of nM against ALK WT, nM against ALK L1196M, and nM against ALK G1202R. Moreover, ALK-IN-21 effectively suppresses proliferation in ALK-positive Karpas299 and H2228 cells, achieving IC50 values of μM. It is applicable for anaplastic large cell lymphoma research [1].