简介内容：MS9427 is a potent PROTAC EGFR degrader, demonstrating high affinity for EGFR with dissociation constants (K d s) of nM for the wild-type (WT) EGFR and nM for the L858R mutant EGFR, indicating selective degradation of the mutant over the WT EGFR. This degradation occurs through both ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. Furthermore, MS9427 effectively inhibits the proliferation of non-small cell lung cancer (NSCLC) cells, positioning it as a potential therape
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