简介内容:CKLF1-C27, a C-terminal peptide of CKLF1, effectively binds to and activates the CCR4 receptor, thereby triggering the ERK1/2 pathway. It competes with CKLF1 for the CCR4 receptor, neutralizing CKLF1´s cellular effects. Furthermore, CKLF1-C27 significantly promotes the proliferation of HUVECs and holds promise for psoriasis research [1].