Talacotuzumab；塔妥珠单抗CSL 362|||JNJ 56022473；CSL 362|||JNJ 56022473T76883

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产品名称：Talacotuzumab；塔妥珠单抗CSL 362|||JNJ 56022473；CSL 362|||JNJ 56022473
产品型号：T76883
产品产地：中国大陆
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简介内容：Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affinity for CD123, CD32b/c, CD16-158F and CD16-158V, with KD of nM, 188 nM, 46 nM and nM, respectively. Talacotuzumab inhibits IL-3 signaling in target cells by inhibiting IL-3 binding to CD123. Talacotuzumab induces mutations in the Fc region to increase affinity for CD16 (FCγriiia), thereby enhancing antibody-dependent cell-media

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原创作者：上海陶术生物科技有限公司

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