简介内容:MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while concurrently suppressing DNA damage response pathways. Its structure comprises a CBP/p300 binding domain, a p53Y220C targeting moiety, and a connecting linker [1].