简介内容：AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4;11 cells with an IC50 of nM. This degradation activates the p21/Rb axis, resulting in antitumor activity. Furthermore, AD4 has been demonstrated to prolong survival in NOD/SCID mice transplanted with RS4;11 cells, showcasing its in vivo efficacy [1].
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