TWIK-1/TREK-1-IN-1；化合物 TWIK-1/TREK-1-IN-1TWIK-1/TREK-1-IN-1T78868

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产品名称：TWIK-1/TREK-1-IN-1；化合物 TWIK-1/TREK-1-IN-1TWIK-1/TREK-1-IN-1
产品型号：T78868
产品产地：中国大陆
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简介内容：Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers and TWIK-1/TREK-1 heterodimers, both significant for its role as an antidepressant target. Furthermore, TWIK-1/TREK-1-IN-3, a related compound, selectively inhibits these channels with IC50 values of μM for TREK-1 homodimers and μM for TWIK-1/TREK-1 heterodimers, demonstrating antidepressant-like effects [1].

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原创作者：上海陶术生物科技有限公司

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