简介内容：CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase. It upregulates caspase-9 and the apoptosis marker Bax, while downregulating the anti-apoptotic marker Bcl-xL. By inhibiting de novo lipogenesis, CTL-12 thwarts tumor cells´ metabolic requirements and is frequently employed in breast and colorectal cancer studies [1].
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