简介内容：SA09-Cu is a potent, noncompetitive inhibitor of NDM-1, with an IC50 of nM. It inactivates NDM-1 by oxidizing the enzyme´s Zn(II)-thiolate site and resists reduction by bacterial intracellular thiols. SA09-Cu effectively restores Meropenem efficacy against various clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) and hampers the progression of carbapenem resistance [1].
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