简介内容：PTD10, a highly potent PROTAC BTK degrader, exhibits a DC50 of nM and a KD of nM. It effectively degrades BTK in Ramos and JeKo-1 cells with respective DC50 values of nM and nM. Additionally, PTD10 inhibits cell growth and triggers apoptosis through the activation of both the caspase-dependent and mitochondrial pathways, making it suitable for research on B-cell dysregulation [1].
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