hCA/VEGFR-2-IN-3；化合物 hCA/VEGFR-2-IN-3hCA/VEGFR-2-IN-3T79588

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产品名称：hCA/VEGFR-2-IN-3；化合物 hCA/VEGFR-2-IN-3hCA/VEGFR-2-IN-3
产品型号：T79588
产品产地：中国大陆
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简介内容：hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. This compound inhibits VEGFR-2 with an IC50 of 358 nM and exhibits high affinity for hCAs, evidenced by Ki values of nM for hCA IX, nM for hCA II, nM for hCA I, and nM for hCA XII. Additionally, hCA/VEGFR-2-IN-3 demonstrates antiproliferative activity specifically against breast cancer cells that overexpress VEGFR-2 [1].

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原创作者：上海陶术生物科技有限公司

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