简介内容:UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of ± μM. It impedes 53BP1´s recruitment to DNA double-strand breaks (DSBs), maintaining the protein´s autoinhibited state within cells [1].