GW274150 dihydrochloride；化合物 GW274150 dihydrochlorideGW274150 dihydrochlorideT82251

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产品名称：GW274150 dihydrochloride；化合物 GW274150 dihydrochlorideGW274150 dihydrochloride
产品型号：T82251
产品产地：中国大陆
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简介内容：GW274150 (dihydrochloride) is a potent, selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of μM and Kd of 40 nM for human iNOS, and an ED50 of μM for rat iNOS. It demonstrates reduced effectiveness against endothelial NOS (eNOS) and neuronal NOS (nNOS) in both species. The compound has been shown to confer protective effects in acute lung injury inflammation models [1] [2] [3].

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