简介内容:Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA receptor NR2B subunit. At a concentration of 10 ?M, Tat-CBD3 reduces the interaction by 43% in cell-free assays and impedes the NMDA receptor NR2B subunit-CRMP2 interaction in immunoprecipitation assays. It lowers voltage-induced calcium currents by about 60% in prim