简介内容:TG2-179-1 is a BRCA1-associated protein 1 (BAP1) inhibitor that effectively hampers BAP1´s deubiquitinase activity in cell-free assays at concentrations between 25 ?M and mM. This compound exhibits cytotoxicity towards a range of eight colon cancer cell lines, with half-maximal inhibitory concentrations (IC50s) spanning from to ?M. Additionally, in an HCT116 colon cancer mouse xenograft model, TG2-179-1 administration at doses of 10 and 30 mg/kg significantly reduces tumor vo