Soluble Epoxide Hydrolase PROTAC 1a；化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targetingT83857

当前位置:上海陶术生物科技有限公司>产品中心>活性小分子抑制剂 > Soluble Epoxide Hydrolase PROTAC 1a；化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targeting

联系我们

产品目录

仪器耗材

天然产物

试剂盒

介绍

产品展示/Products

产品名称：Soluble Epoxide Hydrolase PROTAC 1a；化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targeting
产品型号：T83857
产品产地：中国大陆
采购热度：
简介内容：Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its hydrolase activity (IC50 = nM) significantly more than its phosphatase activity (IC50 = >10,000 nM). This compound preferentially targets cytosolic sEH for lysosomal rather than proteasomal degradation. Furthermore, it mitigates thapsigargin-induced upregulation of phosphoryla

详细内容/Content

原创作者：上海陶术生物科技有限公司

Soluble Epoxide Hydrolase PROTAC 1a；化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targeting产品询价/message

同类相关产品/congeneric Product

4008200310

15002134094

工作时间

9:00-18:00

展开客服

第5年