C 101248；化合物 C 101248C 101248T83962 - 上海陶术生物科技有限公司

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产品名称：C 101248；化合物 C 101248C 101248
产品型号：T83962
产品产地：中国大陆
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简介内容：C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and . This compound effectively blocks tonic and ATP-evoked THIK-1 K+ currents as observed in whole-cell patch-clamp recordings of mouse hippocampal microglia. Additionally, C 101248 mitigates neuroinflammation by inhibiting the NLRP3-dependent release of IL-1β in isolated microglia.

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名称: C 101248；化合物 C 101248

描述: 化合物 C 101248。

关键字: C 101248 |

原创作者：上海陶术生物科技有限公司

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